Located in south-western of Yun Nan-Gui Zhou Plateau, Guiyang city is the important traffic hub in south-western region. Currently, obvious water resource problems impede local economic and social development. To solve water resource problems, our professionals undertake water resource comprehensive management project. We analyze and research water resource management situation and the challenges, make reference for international experience, and integrate different steps on water resource protection, development, utilization, analyze and research problems such as urban flood control, flood drain, water supply, water saving, sewage treatment and water environment protection and government, arise suggestion on water integration. The implementation of related works will enhance water resource management level comprehensively, efficiently relieve water resource demand-supply contradiction, and push forward social and economic sustainable development.